Design, Synthesis, Spectral Characterization, DNA Binding and Antibacterial Studies of Ternary Metal Complexes with 1,10 Phenanthroline and 2-Acetylthiophene-4-phenyl-3-thiosemicarbazone

Bivalent metal complexes having the composition M(Phen)Cl2 (where, M = Cu(II), Ni(II) and Co(II); Phen 1,10-Phenonthroline) are reacted with 2-acetylthiophene-4-phenyl-3-thiosemicarbazone (ATPT) to produce ternary molecular formula [M(Phen)(ATPT)Cl2] H2O. The characterized using physical (molar conductivity) spectral (mass spectra, infrared electronic spectroscopies) methods. Electrochemical behavior of was uncovered cyclic voltammetry. DNA binding properties determined by absorption UV-Visible spectrophotometry. Metal screened for their antibacterial activity agar well diffusion method against pathogenic bacterial strains viz. Gram–ve such as Escherichia coli, Klebsiella Pneumonia Gram+ve Staphylococcus aureus, Bacillus cereus. [Ni (Phen)(ATPT)Cl2] 0.5 H2O complex inhibits bacteria more stronger than any other complex.
 HIGHLIGHTS
 
 Ternary Complexes 1,10 Phenanthroline 2-Acetylthiophene-4-phenyl-3-thiosemicarbazone synthesized
 physico-chemical, electrochemical methods
 determined
 activity
 effectively
 GRAPHICAL ABSTRACT